IS: Otoko demo Onna demo Nai Sei

This is not your everyday manga. It strictly deals with cases of intersexuality. I.S. stands for Inter Sexuality.

This manga deals with the struggles of intersex people: the pain they go through, the troubles they confront, and ultimately their inability to reproduce or even find a partner who will accept them as they are.

The series broken down into individual cases; each deals with different people, though some cases are much longer and more dramatic than others.